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Sunday, 31 March 2019

Hypersensitivity 1.

h. S -.
ige ..  igm - igg.
il-4- igm - ige.
allos - other.  argon - reactivity.

allergen - 1. sensitization.
2.sbquent - serious.

apc - dendrite + macropage - antigen ko lekar lymph nodes me dal dete hain - check karne ke liye banda allergic hai yea nhi - then apc se th2 milta hai - wo cd4 se joint hota hai then - t cell - plasma cell ko.. active karta hai.. plasama cell.. antibody release karta hai -  naive t cell - to primed t h cell -

integulatory t cell - il 4 - 5 - 6..

il4: - igm - ige -
il5 - eosinophil production - degranulation.

fce receptor on mast cell - ige attach to it.

Senstizatization end.. isme histamin release nhi hoga.. histamine.. Sbqunet phase me release hoga.

2nd time - direct mast cell se milega.. - then ye direct release karega histamin - vascular permeability - edmea.. red patch - bronchial contraction much more.
early phase bolte hain ise.


late phase -
Leuckotriens - ltb4 + ltc4
- attaract more neutrophil + mast cell.

anaphylactic shock - bronchial contraction.. lead to low blood supply to vital organ - so brain low oxygen - anaphylactic shock.



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